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Melanoma treatment details. Biologic therapy. Toulouse III University and Larrey Hospital, Toulouse, France

Survival: 3.3 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: France
City/State/Province: Toulouse
Hospital: Toulouse III University and Larrey Hospital
Journal: Link
Date: 7/2013

This study involved 38 metastatic melanoma patients with brain metastasis. The median patient age was 50 years and 68.4% were male.

Patients were treated with the biologic therapy agent called ipilimumab, which is a monoclonal antibody recognizing CTLA-4 that works to help the immune system attack tumor cells.

There were eight treatment-related deaths due to intracranial hemorrhage and intracranial hypertension. Grade 3 fatigue and enterocolitis (inflammation of the digestive tract) were also reported.

The median overall survival was 3.3 months.

Study drug was provided by Bristol-Myers Squibb, makers of ipilimumab.

Correspondence: Dr. Nicolas Meyer; email:

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