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Mesothelioma Cancer treatment details. Biologic therapy. University of Western Australia, Crawley, WA, Australia



Survival: 8.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Australia
   
City/State/Province: Crawley, WA
   
Hospital: University of Western Australia
   
Journal: Link
   
Date: 9/2013

Description:
Patients:
This phase 2 study involved 30 advanced malignant pleural mesothelioma patients. The median patient age was 64 years and 27 were male.

Treatment:
Patients were treated with the biologic therapy agent called BNC105P, which is an inhibitor of tubulin polymerization that disrupts tumor blood supply and inhibits cancer cell growth.

Toxicities:
There were two treatment-related deaths due to pneumonia and cardiorespiratory failure. Grade 4 blood clots and grade 3 fatigue were also reported.

Results:
The median overall survival was 8.2 months.

Support:
This study was supported by Bionomics, makers of BNC105P.

Correspondence: Dr. ; email: anna.nowak@uwa.edu.au

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