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Mesothelioma Cancer treatment details. Biologic therapy. Chemotherapy. The Royal Marsden NHS Foundation, Surrey, United Kingdom



Survival: 13.5 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Surrey
   
Hospital: The Royal Marsden NHS Foundation
   
Journal: Link
   
Date: 9/2013

Description:
Patients:
This phase 2 study involved 82 malignant pleural mesothelioma patients who had not received prior chemotherapy. The median patient age was 55 years and 67.1% were male.

Treatment:
Patients were treated with the chemotherapy agent cisplatin and the biologic therapy agent called bortezomib, which is a proteasome inhibitor that causes cancer cell death.

Toxicities:
There were two treatment-related deaths due to lung inflammation and heart attack. Grade 4 pain and nerve toxicity were also reported.

Results:
The median overall survival was 13.5 months.

Support:
This study was partially supported by Johnson & Johnson.

Correspondence: Dr. Mary E.R. O’Brien; email: mary.obrien@rmh.nhs.uk

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