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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. The University of Texas MD Anderson Cancer Center, Houston, Texas, United States



Survival: 10.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: The University of Texas MD Anderson Cancer Center
   
Journal: Link
   
Date: 9/2013

Description:
Patients:
This phase 2 study involved 45 patients with diffuse large B-cell lymphoma, transformed large cell lymphoma, or grade 3 follicular lymphoma. The median patient age was 66 years and 62% were male.

Treatment:
Patients were treated with the biologic therapy agent rituximab (monoclonal antibody for CD20 that directs the immune system to kill cancer cells) and the immunomodulatory (biologic) agent called lenalidomide that interferes with cancer cell growth.

Toxicities:
There was one death due to “natural causes” during the study that may have been due to treatment. Grade 4 neutropenia, thrombocytopenia, and leukopenia were also reported.

Results:
The median overall survival was 10.7 months.

Support:
Some of the authors have received funding from Celgene Corporation.

Correspondence: Dr. M Wang; email: miwang@mdanderson.org

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