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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, United States



Survival: 17.8 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Los Angeles, CA
   
Hospital: University of Southern California Norris Comprehensive Cancer Center
   
Journal: Link
   
Date: 8/2013

Description:
Patients:
This phase 3 study involved advanced castration-resistant prostate cancer patients who were divided into two separate treatment groups. Group A had 496 patients with a median age of 69 years. There were 498 patients in group B with a median age of 69 years.

Treatment:
Patients in group A were treated with the chemotherapy agent docetaxel.

Patients in group B were treated with docetaxel and the biologic therapy agent called atrasentan, which is an inhibitor of the endothelin receptor and may inhibit cancer metastases.

Toxicities:
There were seven treatment-related deaths in group A due to respiratory failure, infection, heart failure, and skin toxicity.

There were three treatment-related deaths in group B due to bleeding and infection.

Results:
The median overall survival in groups A and B was 17.6 and 17.8 months, respectively.

Support:
This study was partially supported by Sanofi-Aventis and Abbott Laboratories.

Correspondence: Dr. David I Quinn; email: diquinn@med.usc.edu

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