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Colon Cancer treatment details. Biologic therapy. Mayo Clinic, Rochester, MN, United States

Survival: 6.4 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 1/2013

This phase 3 study involved 505 previously treated metastatic colorectal cancer patients. The median patient age was 61 years and 62% were male.

Patients were treated with the biologic therapy agent called regorafenib, which is a small-molecule multikinase inhibitor that interferes with cancer cell growth.

There were 8 treatment-related deaths due to pneumonia (2), gastrointestinal bleeding (2), intestinal obstruction (1), pulmonary hemorrhage (1), seizure (1), and sudden death (1). Grade 4 fatigue and grade 3 hand-foot skin reaction were also reported.

The median overall survival was 6.4 months.

This study was supported by Bayer HealthCare Pharmaceuticals.

Correspondence: Dr. Eric Van Cutsem; email:

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