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Colon Cancer treatment details. Biologic therapy. Mayo Clinic, Rochester, MN, United States



Survival: 6.4 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 1/2013

Description:
Patients:
This phase 3 study involved 505 previously treated metastatic colorectal cancer patients. The median patient age was 61 years and 62% were male.

Treatment:
Patients were treated with the biologic therapy agent called regorafenib, which is a small-molecule multikinase inhibitor that interferes with cancer cell growth.

Toxicities:
There were 8 treatment-related deaths due to pneumonia (2), gastrointestinal bleeding (2), intestinal obstruction (1), pulmonary hemorrhage (1), seizure (1), and sudden death (1). Grade 4 fatigue and grade 3 hand-foot skin reaction were also reported.

Results:
The median overall survival was 6.4 months.

Support:
This study was supported by Bayer HealthCare Pharmaceuticals.

Correspondence: Dr. Eric Van Cutsem; email: eric.vancutsem@uzleuven.be

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