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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Prosper Hospital Recklinghausen, Recklinghausen, Germany



Survival: 23.2 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Germany
   
City/State/Province: Recklinghausen
   
Hospital: Prosper Hospital Recklinghausen
   
Journal: Link
   
Date: 9/2013

Description:
Patients:
This phase 2 study involved 49 metastatic colorectal cancer patients who had not been previously treated. The median patient age was 63.4 years and 76% were male.

Treatment:
Patients were treated with the chemotherapy agents capecitabine and oxaliplatin, and the biologic therapy agents bevacizumab (an angiogenesis inhibitor that interferes with tumor blood supply) and imatinib (a protein kinase inhibitor that interferes with cancer cell growth).

Toxicities:
The most severe toxicities were of grade 3 and included nerve toxicity, diarrhea, vomiting, and neutropenia.

Results:
The median overall survival was 23.2 months.

Support:
This study was supported by Roche Pharma AG, Novartis and Sanofi-Aventis.

Correspondence: Dr. U T Hacker; email: ulrich.hacker@medizin.uni-leipzig.de

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