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Colon Cancer treatment details. Biologic therapy. Chemotherapy. Azienda Ospedaliera-Universitaria Pisana, Pisa, Italy



Survival: 24.1 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Italy
   
City/State/Province: Pisa
   
Hospital: Azienda Ospedaliera-Universitaria Pisana
   
Journal: Link
   
Date: 10/2013

Description:
Patients:
This study involved 15 metastatic colorectal cancer patients who had the BRAF genetic mutation. The median patient age was 56 years and 40% were male.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab (an angiogenesis inhibitor that interferes with tumor blood supply) and the chemotherapy agents irinotecan, oxaliplatin, leucovorin, and 5-fluorouracil.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 neutropenia, stomatitis (inflammation of the GI tract lining), and diarrhea.

Results:
The median overall survival was 24.1 months.

Correspondence: Dr. F. Loupakis; email: fotiosloupakis@gmail.com

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