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Rectal Cancer treatment details. Chemotherapy. Radiation. Surgery. Anti-Cancer Council of Victoria, Melbourne, Australia



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: Adrucil
Leucovorin
Country: Australia
   
City/State/Province: Melbourne
   
Hospital: Anti-Cancer Council of Victoria
   
Journal: Link
   
Date: 8/2001

Description:
Patients: This Phase II study involved 42 patients with stage T3 or T4 adenocarcinoma of the rectum.

Treatment: Teatment consisted of systemic chemotherapy, 5-fluorouracil (adrucil) and leucovorin with radiotherapy followed by surgery. Twenty-four patients also received the same chemotherapy post-operatively (after surgery).

Toxicity: Grade 4 toxicities related to the chemo-radiation included: diarrhea, stomatitis, and granulocytes. Grade 1-3 chemo-radiation toxicities included: nausea and vomiting, diarrhea, stomatitis, perineal dermatitis, alopecia (grade1-2 only), infection, hemorrhage (grade1-2 only), bladder frequency, cystitis, granulocytes (grade1-2 only), and platelets (grade1-2 only). jor surgical complications occurred in 7 patients.

Results: Overall survival was not discussed.

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