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Melanoma treatment details. Biologic therapy. Chemotherapy. Azienda Ospedaliera Universitaria Senese, Siena, Italy



Survival: 13.3 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Italy
   
City/State/Province: Siena
   
Hospital: Azienda Ospedaliera Universitaria Senese
   
Journal: Link
   
Date: 9/2012

Description:
Patients:
This phase 2 study involved 86 advanced melanoma patients. The median patient age was 54 years and 70% were male.

Treatment:
Patients were treated with the biologic therapy agent ipilimumab (a monoclonal antibody that inhibits the CTLA-4 protein and enhances the anti-tumor immune response) and the chemotherapy agent fotemustine.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 thrombocytopenia, neutropenia, and liver toxicity.

Results:
The median overall survival was 13.3 months.

Support:
This study was supported by Bristol-Myers Squibb.

Correspondence: Dr. Michele Maio; email: mmaio@cro.it

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