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Melanoma treatment details. Biologic therapy. Immunotherapy. The Ohio State University, Columbus, OH, United States



Survival: 17.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Columbus, OH
   
Hospital: The Ohio State University
   
Journal: Link
   
Date: 7/2011

Description:
Patients:
This phase 2 study involved 25 metastatic melanoma patients. The median patient age was 56 years and 16 were male.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab and the immunotherapy agent interferon alpha-2B (IFN-alpha) which stimulates the immune system to fight the cancer.

Toxicities:
There was one reported adverse event-related death due to stroke. Grade 3-4 blood clots, joint pain, and neutropenia were also reported.

Results:
The median overall survival was 17 months.

Support:
Some of the researchers have consulted for or received funding from Genentech.

Correspondence: Dr. William E. Carson; email: william.carson@osumc.edu

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