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Mesothelioma Cancer treatment details. Biologic therapy. Azienda Ospedaliera Universitaria Senese, Siena, Italy



Survival: 10.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Siena
   
Hospital: Azienda Ospedaliera Universitaria Senese
   
Journal: Link
   
Date: 10/2013

Description:
Patients:
This phase 2 study involved 29 advanced malignant mesothelioma patients who had received previous platinum-based chemotherapy. The median patient age was 64 years and 72% were male.

Treatment:
Patients were treated with the biologic therapy agent called tremelimumab, a monoclonal antibody that inhibits the CTLA-4 protein and enhances the anti-tumor immune response.

Toxicities:
The most severe toxicities were grade 4 liver toxicity. Grade 3 gastrointestinal and nerve toxicities were also reported.

Results:
The median overall survival was 10.7 months.

Support:
This study was partially supported by Pfizer.

Correspondence: Dr. Michele Maio; email: mmaio@cro.it

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