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Ovarian Cancer treatment details. Chemotherapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 35.2 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 6/2012

Description:
Patients:
This phase 3 study involved platinum-sensitive recurrent ovarian, primary peritoneal, or fallopian tube cancer patients who had received prior platinum-based chemotherapy. Patients were divided into two separate treatment groups. Group A had 242 patients with a median age of 61 years, while group B had 242 patients with a median age of 60 years.

Treatment:
Patients in group A were treated with the chemotherapy agents gemcitabine and carboplatin.

Patients in group B were treated with the biologic therapy agent bevacizumab and the chemotherapy agents gemcitabine and carboplatin.

Toxicities:
One treatment-related death due to heart attack was reported for group A. Grade 4 neutropenia was also reported.

One adverse event-related death due to brain hemorrhage was reported for group B. Grade 4 neutropenia and grade 3-4 high blood pressure were also reported.

Results:
The median overall survival times for groups A and B were 35.2 and 33.3 months, respectively.

Support:
This study was supported by Genentech.

Correspondence: Dr. Carol Aghajanian; email: aghajanc@mskcc.org

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