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Rectal Cancer treatment details. Chemotherapy. Radiation. Surgery. Washington University School of Medicine, St. Louis Missouri, United States



Survival: ?
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: Adrucil
Leucovorin
Country: United States
   
City/State/Province: St. Louis Missouri
   
Hospital: Washington University School of Medicine
   
Journal: Link
   
Date: 8/2001

Description:
Patients: Thirty-seven patients with locally advanced rectal carcinoma were enrolled in this Phase I/II protocol.

Treatment: Treatment consisted of three-dimensionally planned boost radiotherapy with venous infusion of 5-FU (adrucil) chemotherapy, surgery, and postoperative 5-FU/leucovorin.

Toxicity: Acute toxicity was often substantial. Nine of 37 patients experienced grade 3 or 4 toxicities. Toxicities included: proctitis, and small bowel adverse reactions (i.e. ilieus, obstruction, enteritis).

Results: Overall 3 years survival (actuarial) was 82% +/- 7%.

Correspondence: Dr. Robert J. Myerson

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