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Colon Cancer treatment details. Chemotherapy. Radiation. Surgery. Mayo Clinic, Rochester, MN, United States



Survival: ?
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
Surgery
   
Drugs: Adrucil
Ergamisol
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 8/2004

Description:
Patients: This Phase III study involved 187 assessable patients with colon cancer (staged T3 or T4). Patients were divided into two groups. Group 1 comprised 93 patients and Group 2 comprised 94 patients.

Treatment: Group 1 received surgery (complete resection) and chemotherapy comprised of fluorouracil (adrucil) and levamisole (ergamisol). Group 2 received surgery (complete resection) and chemotherapy (fluorouracil and levamisole) plus radiotherapy.

Toxicity: There were two treatment related deaths; one in Group 1 (sepsis) and one in Group 2 (liver failure). For both groups, other toxicities (grade 3 and above) included hematologic, diarrhea, nausea, stomatitis, vomiting, skin, and lethargy.

Results: Overall survival at 5 years was 62% for patients in Group 1 and 58% for patients in Group 2.

Correspondence: James A. Martenson

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