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Brain Cancer treatment details. Biologic therapy. Chemotherapy. Radiation. Cleveland Clinic, Cleveland, OH, United States



Survival: 8.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, OH
   
Hospital: Cleveland Clinic
   
Journal: Link
   
Date: 5/2010

Description:
Patients:
This phase 2 study involved 27 newly diagnosed glioblastoma patients with a median age of 52 years; 63% were male.

Treatment:
Patients were treated with radiation therapy, chemotherapy with temozolomide, and the biologic therapy agent erlotinib, which is a tyrosine kinase inhibitor that interferes with tumor blood supply.

Toxicities:
Treatment-related deaths due to pneumonia and other infections were reported. Grade 4 thrombocytopenia and grade 3 fatigue were also reported.

Results:
The median progression-free survival was 2.8 months and the median overall survival was 8.6 months.

Correspondence: Dr. David M. Peereboom; email: peerebd@ccf.org

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