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Breast Cancer treatment details. Biologic therapy. Jules Bordet Institute, Brussels, Belgium



Survival: 19.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: Belgium
   
City/State/Province: Brussels
   
Hospital: Jules Bordet Institute
   
Journal: Link
   
Date: 12/2013

Description:
Patients:
This phase 2 study involved female, previously treated, HER2+, locally advanced/metastatic breast cancer patients who were divided into two separate treatment groups. Group A had 117 patients with a median age of 52 years. Group B had 116 patients with a median age of 56 years.

Treatment:
Patients in group A were treated with the biologic therapy agent neratinib, which is a tyrosine kinase inhibitor that interferes with tumor growth.

Patients in group B received chemotherapy with capecitabine and biologic therapy with lapatinib, which is a tyrosine kinase inhibitor that interferes with tumor growth.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 diarrhea, nausea, and vomiting.

The most severe toxicities were of grade 4 and included grade 3-4 hand-foot syndrome (skin reaction), diarrhea, and stomatitis (inflammation of the GI tract).

Results:
The median overall survival times for groups A and B were 19.7 and 23.6 months, respectively.

Support:
This study was supported by Wyeth Research.

Correspondence: Dr. Ahmad Awada; email: ahmad.awada@bordet.be

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