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Melanoma treatment details. Biologic therapy. Mayo Clinic, Rochester, MN, United States



Survival: 9.7 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 12/2013

Description:
Patients:
This phase 2 study involved 29 patients with metastatic melanoma overexpressing the FGF-2 protein. The median patient age was 64 years and 69% were male.

Treatment:
Patients were given biologic therapy with peginterferon alpha-2b (Peg-IFN), a form of a cytokine that is used in this study to interfere with factors involved in tumor blood supply.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 fatigue, nausea, and infection.

Results:
The median overall survival was 9.7 months.

Support:
Some of the study’s authors received funding from various pharmaceutical companies.

Correspondence: Dr. Ronald S. Go; email: Go.Ronald@mayo.edu

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