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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Washington University School of Medicine, St. Louis, MO, United States



Survival: 25.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: Pemetrexed
Country: United States
   
City/State/Province: St. Louis, MO
   
Hospital: Washington University School of Medicine
   
Journal: Link
   
Date: 12/2013

Description:
Patients:
This phase 2 study involved 34 patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers who had received prior chemotherapy. The average patient age was 61.5 years.

Treatment:
Patients were treated with the biologic therapy agent bevacizumab and the chemotherapy agent pemetrexed.

Toxicities:
There was one treatment-related death attributed to constitutional effects (ie. fatigue, insomnia, weight changes). Grade 4 neutropenia, leukopenia, thrombocytopenia, and pain were also reported.

Results:
The median overall survival was 25.7 months.

Support:
This study was partially supported by Eli Lilly and Genentech.

Correspondence: Dr. Andrea R. Hagemann; email: hagemanna@wudosis.wustl.edu

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