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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. Washington University School of Medicine, St. Louis, MO, United States

Survival: 25.7 months
Toxicity Grade: 5
Treatments: Biologic therapy
Drugs: Pemetrexed
Country: United States
City/State/Province: St. Louis, MO
Hospital: Washington University School of Medicine
Journal: Link
Date: 12/2013

This phase 2 study involved 34 patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancers who had received prior chemotherapy. The average patient age was 61.5 years.

Patients were treated with the biologic therapy agent bevacizumab and the chemotherapy agent pemetrexed.

There was one treatment-related death attributed to constitutional effects (ie. fatigue, insomnia, weight changes). Grade 4 neutropenia, leukopenia, thrombocytopenia, and pain were also reported.

The median overall survival was 25.7 months.

This study was partially supported by Eli Lilly and Genentech.

Correspondence: Dr. Andrea R. Hagemann; email:

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