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Bladder Cancer treatment details. Biologic therapy. University of Chicago, Chicago, Il, United States

Survival: 8.5 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Chicago, Il
Hospital: University of Chicago
Journal: Link
Date: 4/2014

This phase 2 study involved 50 advanced or metastatic urothelial cancer patients who had received previous chemotherapy. The median patient age was 68.5 years and 80% were male.

Patients were treated with the biological therapy agent called volasertib, which is an inhibitor of the PIK protein that interferes with cancer cell growth.

There were 3 reported deaths due to disease progression. Grade 3-4 anemia, thrombocytopenia, and neutropenia were also reported.

The median overall survival was 8.5 months.

This study was partially supported by Boehringer Ingelheim.

Correspondence: Dr. Walter M. Stadler; email:

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