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Breast Cancer treatment details. Biologic therapy. Chemotherapy. Immunotherapy. The University of Texas MD Anderson Cancer Center, Houston, TX, United States



Survival: 31.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, TX
   
Hospital: The University of Texas MD Anderson Cancer Center
   
Journal: Link
   
Date: 9/2013

Description:
Patients:
This study involved 10 HER2-positive metastatic breast cancer patients with a median age of 46.5 years. One patient was male.

Treatment:
Patients were treated with high dose chemotherapy (HDC; with cyclophosphamide, carmustine, and thiotepa) immune therapy with autologous hematopoietic stem cell transplantation, the chemotherapy agent paclitaxel, and the biologic therapy agent trastuzumab.

Toxicities:
The most severe toxicities were grade 4 neutropenia and thrombocytopenia. Grade 3 infection, nausea, and cardiac toxicity were also reported.

Results:
The median overall survival was 31.4 months.

Correspondence: Dr. Naoto T. Ueno; email: nueno@mdanderson.org

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