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Liver Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 8.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 2/2014

Description:
Patients:
This phase 2 study involved 24 advanced hepatocellular carcinoma patients. The median patient age was 67.5 years and 83% were male.

Treatment:
Patients received biologic therapy with cixutumumab, which is a monoclonal antibody to the IGF-1R protein that inhibits cancer cell growth.

Toxicities:
There was one treatment-related death due to kidney failure. Grade 3 high blood glucose and grade 3-4 liver toxicities were also reported.

Results:
The median overall survival was 8 months.

Support:
This study was partially supported by ImClone Systems, makers of cixutumumab.

Correspondence: Dr. Ghassan K. Abou-Alfa; email: abou-alg@mskcc.org

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