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Lung Cancer treatment details. Biologic therapy. Institut Gustave Roussy, Villejuif, France



Survival: 9.7 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: France
   
City/State/Province: Villejuif
   
Hospital: Institut Gustave Roussy
   
Journal: Link
   
Date: 2/2014

Description:
Patients:
This phase 2 study involved previously treated advanced non-small cell lung cancer patients who were divided into two treatment groups. In group A, there were 66 patients with a median age of 60 years; 54.5% were men. Group B had 67 patients with a median age of 60.5 years and 49.3% were men.

Treatment:
Patients in group A were treated with the biological therapy agents everolimus (an inhibitor of mTOR) and erlotinib (a tyrosine kinase inhibitor of the EGFR protein).

Patients in group B were treated with erlotinib alone.

Toxicities:
There was one treatment-related death in group A due to heart attack. Grade 4 anemia and grade 3 stomatitis were also reported.

There was one treatment-related death in group B due to anaphylactic shock. Grade 4 shortness of breath was also reported.

Results:
The median overall survival rates for groups A and B were 9.1 and 9.7 months, respectively.

Support:
This study was supported by Novartis.

Correspondence: Dr. Benjamin Besse; email: benjamin.besse@gustaveroussy.fr

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