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Colon Cancer treatment details. Chemotherapy. Vienna University Medical School, Vienna, Austria



Survival: ?
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
   
Drugs: Adrucil
Leucovorin
Xeloda
Country: Austria
   
City/State/Province: Vienna
   
Hospital: Vienna University Medical School
   
Journal: Link
   
Date: 12/2003

Description:
Patients: This Phase II study involved 1,967 patients with resected Dukes' C colon carcinoma. Patients were divided into two groups: Group 1 comprised 993 patients and Group 2 comprised 974 patients.

Treatment: Patients in Group 1 were treated with the chemotherapy drug, capecitabine (xeloda). Patients in Group 2 were treated with two chemotherapy drugs, 5-FU (adrucil) and leucovorin.

Toxicity: There were three treatment related deaths in Group 1 (multi-organ failure, septic shock, and pneumonia). There were four treatment related deaths in Group 2 (severe diarrhea and vomiting, respiratory arrest, gastrointestinal hemorrhage, bronchopneumonia).

Results: Survival results were not discussed.

Support: This research was sponsored by F. Hoffman-La Roche, Ltd. Roche markets capecitabine.

Correspondence: Prof. W. Scheithauer

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