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Non-Hodgkin's Lymphoma treatment details. Biologic therapy. Chemotherapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 18.0 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 1/2014

Description:
Patients:
This phase 2 study involved 37 advanced cutaneous T cell lymphoma patients. The median patient age was 56 years and 54% were male.

Treatment:
Patients were treated with the chemotherapy agent doxorubicin HCl liposome injection and the biologic therapy agent bexarotene (a synthetic retinoid that targets the RXR receptor).

Toxicities:
There was one treatment-related death due to congestive heart failure. Severe hand-foot syndrome, neutropenia, and stomatitis were also reported.

Results:
The median overall survival was 18 months.

Support:
This study was supported by Janssen Pharmaceuticals.

Correspondence: Dr. David J. Straus; email: strausd@mskcc.org

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