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Bladder Cancer treatment details. Biologic therapy. Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy



Survival: 8.0 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Milan
   
Hospital: Fondazione IRCCS Istituto Nazionale dei Tumori
   
Journal: Link
   
Date: 2/2014

Description:
Patients:
This phase 2 study involved 14 pre-treated metastatic urothelial cancer patients. The median patient age was 64 years and 13 were male.

Treatment:
Patients were treated with the biologic therapy agent called PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1 that interferes with cancer cell growth.

Toxicities:
The most severe toxicity was grade 3 thrombocytopenia. Grade 1-2 fatigue and abdominal pain were also reported.

Results:
The median overall survival was 8 months.

Support:
This study was supported by Pfizer.

Correspondence: Dr. Andrea Necchi; email: andrea.necchi@istitutotumori.mi.it

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