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Breast Cancer treatment details. Chemotherapy. Medical Center Alkmaar, Alkmaar, Netherlands

Survival: 13.8 months
Toxicity Grade: 3
Treatments: Chemotherapy
Country: Netherlands
City/State/Province: Alkmaar
Hospital: Medical Center Alkmaar
Journal: Link
Date: 3/2014

This phase 3 study involved elderly (65 years or older) female metastatic breast cancer patients who were divided into two different treatment groups. Group A consisted of 40 patients, while group B had 38 patients.

Patients in group A were treated with the chemotherapy agent pegylated liposomal doxorubicin (PLD).

Patients in group B received chemotherapy with capecitabine.

The most severe toxicities in group A were of grade 3 and included fatigue, hand-foot syndrome (skin toxicity), and stomatitis (inflammation of the stomach lining).

There was one treatment-related death due to gastrointestinal bleeding in group B. Grade 3 fatigue, hand-foot syndrome (skin toxicity), and diarrhea were also reported.

The median overall survival rates in group A and B were 13.8 and 16.8 months, respectively.

This study was supported by the following pharmaceutical companies: Amgen, Schering Plough, and Janssen Cilag.

Correspondence: Dr. C. H. Smorenburg; email:

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