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Lung Cancer treatment details. Biologic therapy. Chemotherapy. St Jamesís University Hospital, Leeds, United Kingdom



Survival: 10.6 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United Kingdom
   
City/State/Province: Leeds
   
Hospital: St Jamesís University Hospital
   
Journal: Link
   
Date: 1/2014

Description:
Patients:
This phase 2 study involved advanced non-small cell lung cancer patients who were divided into two separate treatment groups. Group A consisted of 58 patients with an average age of 61.7 years and 62.1% males. Group B had 60 patients with an average age of 59.9 years and 61.7% males.

Treatment:
Patients in group A received chemotherapy with paclitaxel and carboplatin, and biologic therapy with axitinib (a VEGF receptor inhibitor that interferes with tumor growth).

Patients in group A received chemotherapy with paclitaxel and carboplatin, and biologic therapy with bevacizumab.

Toxicities:
Treatment-related deaths due to heart attack, sepsis, and respiratory distress were reported for group A. Diarrhea and neutropenia were also reported.

Treatment-related deaths due to deterioration of general physical health and coughing up blood were reported for group B. Alopecia and fatigue were also reported.

Results:
The median overall survival rates for groups A and B were 10.6 and 13.3 months, respectively.

Support:
This study was supported by Pfizer.

Correspondence: Dr. Chris Twelves; email: c.j.twelves@leeds.ac.uk

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