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Colon Cancer treatment details. Chemotherapy. Immunotherapy. Surgery. Vrije Universiteit Medical Center, Amsterdam, Netherlands

Survival: ?
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Adrucil
Country: Netherlands
City/State/Province: Amsterdam
Hospital: Vrije Universiteit Medical Center
Journal: Link
Date: 4/2002

Patients: This Phase II study involved 56 patients with colon cancer (stage III).

Treatment: Treatment consisted of surgery followed autologous tumour cell vaccinations and the chemotherapy drugs 5-Fluorouracil (adrucil) and leucovorin.

Toxicity: One patient died of multiple organ failure resulting from the toxicity of 5-FU. In addition, thirty percent of patients experienced grade 3 or 4 toxicity including diarrhea, ileus, mucositis, nausea, vomiting, febrile neutropenia, and deep vein thrombosis.

Results: Overall survival was not discussed.

Support: The study was financially supported by Intracel Corporation. Intracel is a biotechnology company that develops and commercializes cancer vaccines.

Correspondence: AJM van den Eertwegh, MD

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