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Ovarian Cancer treatment details. Biologic therapy. Seidman Cancer Center, Cleveland, OH, United States



Survival: 25.9 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: Cleveland, OH
   
Hospital: Seidman Cancer Center
   
Journal: Link
   
Date: 3/2014

Description:
Patients:
This phase 2 study involved women with recurrent platinum-sensitive epithelial ovarian, peritoneal, or fallopian tube cancer who were divided into two separate treatment groups. Group A had 14 patients with an average age of 62 years, while group B had 28 patients with an average age of 62 years.

Treatment:
Patients in group A were treated with the biologic therapy agent sorafenib.

Patients in group B were treated with the biologic therapy agent sorafenib and the chemotherapy agents carboplatin and paclitaxel.

Toxicities:
The most severe toxicities in group A were of grade 3 and included rash, abdominal pain, and fatigue.

The most severe toxicities in group B were grade 4 infusion-related reaction. Grade 3 hand-foot skin reaction, vomiting, and nerve toxicity were also reported.

Results:
The median overall survival rates for groups A and B were 25.6 and 25.9 months, respectively.

Correspondence: Dr. Steven Waggoner; email: steven.waggoner@uhhospitals.org

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