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Bladder Cancer treatment details. Biologic therapy. Chemotherapy. Alexianer Hospital Maria Hilf GmbH, Krefeld, Germany



Survival: 11.2 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: Germany
   
City/State/Province: Krefeld
   
Hospital: Alexianer Hospital Maria Hilf GmbH
   
Journal: Link
   
Date: 3/2014

Description:
Patients:
This phase 2 study involved advanced or metastatic urothelial cancer patients who were separated into two different treatment groups. Group A consisted of 49 patients with a median age of 67.3 years; 37 were males. Group B had 40 patients with a median age of 64.4 years; 29 were males.
Treatment:
Patients in group A received chemotherapy with gemcitabine and cisplatin.

Patients in group B were treated with the chemotherapy agents gemcitabine and cisplatin as well as the biologic sorafenib.

Toxicities:
There was one treatment-related death in group A due to pancytopenia (decreased number of blood cells). Grade 4 thrombocytopenia was also reported.

The most severe toxicity reported in group B was grade 4 thrombocytopenia. Grade 3 leucopenia and diarrhea were also reported.

Results:
The median overall survival rates for groups A and B were 10.4 and 11.2 months, respectively.

Support:
Some of the authors have received funding from various pharmaceutical companies.

Correspondence: Dr. Susanne Krege; email: susanne.krege@alexianer-krefeld.de

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