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Breast Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Survival: 10.6 months
Toxicity Grade: 3
Treatments: Biologic therapy
Country: United States
City/State/Province: New York, NY
Hospital: Memorial Sloan-Kettering Cancer Center
Journal: Link
Date: 6/2014

This phase 2 study involved 22 previously treated, metastatic breast cancer with a median age of 51 years (range 38-70).

Patients were treated with the biologic therapy agent called ganetespib, which is an inhibitor of the Heat Shock Protein 90 (HSP90) that interferes with breast cancer cell growth.

The most severe toxicities were of grade 3 and included abdominal pain, shortness of breath, and diarrhea.

The median overall survival was 10.6 months.

Some of the authors were employed by Synta Pharmaceuticals, Inc., makers of the study drug.

Correspondence: Dr. Shanu Modi; email:

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