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Breast Cancer treatment details. Biologic therapy. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 10.6 months
   
Toxicity Grade: 3
   
Treatments: Biologic therapy
   
Drugs:
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 6/2014

Description:
Patients:
This phase 2 study involved 22 previously treated, metastatic breast cancer with a median age of 51 years (range 38-70).

Treatment:
Patients were treated with the biologic therapy agent called ganetespib, which is an inhibitor of the Heat Shock Protein 90 (HSP90) that interferes with breast cancer cell growth.

Toxicities:
The most severe toxicities were of grade 3 and included abdominal pain, shortness of breath, and diarrhea.

Results:
The median overall survival was 10.6 months.

Support:
Some of the authors were employed by Synta Pharmaceuticals, Inc., makers of the study drug.

Correspondence: Dr. Shanu Modi; email: modis@mskcc.org

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