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Liver Cancer treatment details. Biologic therapy. University of Bologna, Bologna, Italy



Survival: 14.4 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
   
Drugs:
Country: Italy
   
City/State/Province: Bologna
   
Hospital: University of Bologna
   
Journal: Link
   
Date: 4/2014

Description:
Patients:
This study involved previously untreated advanced hepatocellular cancer patients who were divided into two separate treatment groups. Group A consisted of 74 patients with an average age of 71 years; 86.5% were male. Group B had 66 patients with an average age of 66 years; 79.4% were male.

Treatment:
Patients in group A were treated with the biologic sorafenib.

Patients in group B received radiation therapy with transarterial radioembolization (TARE).

Toxicities:
Treatment-related deaths were reported for group A with causes including stroke and liver failure. Grade 3-4 fatigue and hypertension were also reported.

Treatment-related deaths were reported for group B with causes including liver failure, pneumonia, and intestinal bleeding. Grade 3-4 fever was also reported.

Results:
The median overall survival rates for groups A and B were 14.4 and 13.2 months, respectively.

Correspondence: Dr. Annagiulia Gramenzi; email: annagiulia.gramenzi@unibo.it

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