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Liver Cancer treatment details. Biologic therapy. Massachusetts General Hospital Cancer Center, Boston, MA, United States

Survival: 12.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Massachusetts General Hospital Cancer Center
Journal: Link
Date: 12/2013

This phase 2 study involved 42 advanced hepatocellular cancer patients. The median patient age was 63 years and 81% were male.

Patients were treated with the biologic therapy agent called ramucirumab, a monoclonal antibody for the VEGF receptor 2 protein that inhibits cancer cell growth.

There was one treatment-related death due to gastrointestinal hemorrhage. Grade 4 hypertension and grade 1 headache and nausea were also reported.

The median overall survival was 12.0 months.

This study was partially supported by ImClone Systems, which is owned by the pharmaceutical company Eli Lilly.

Correspondence: Dr. Andrew X. Zhu; email:

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