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Melanoma treatment details. Chemotherapy. Aix-Marseille University, Marseille, France

Survival: 6.7 months
Toxicity Grade: 5
Treatments: Chemotherapy
Country: France
City/State/Province: Marseille
Hospital: Aix-Marseille University
Journal: Link
Date: 7/2014

This phase 2 study involved metastatic melanoma patients who were divided into two separate treatment groups. Group A consisted of 168 patients with a median age of 60 years; 61.3% were male. Group B had 168 patients with a median age of 60 years; 62.5% were male.

Patients in group A received chemotherapy with tasisulam.

Patients in group B received chemotherapy with paclitaxel.

There were 13 reported treatment-related deaths in group A due to sepsis/fever (infection).

The most severe toxicities in group B were of grade 4 and included grade 3-4 thrombocytopenia, neutropenia, and diarrhea.

The median overall survival rates for groups A and B were 6.77 and 9.36 months, respectively.

This study was supported by the pharmaceutical company Eli Lilly.

Correspondence: Dr. Jean-Jacques Grob; email:

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