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Melanoma treatment details. Chemotherapy. Aix-Marseille University, Marseille, France



Survival: 9.3 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
   
Drugs:
Country: France
   
City/State/Province: Marseille
   
Hospital: Aix-Marseille University
   
Journal: Link
   
Date: 7/2014

Description:
Patients:
This phase 2 study involved metastatic melanoma patients who were divided into two separate treatment groups. Group A consisted of 168 patients with a median age of 60 years; 61.3% were male. Group B had 168 patients with a median age of 60 years; 62.5% were male.

Treatment:
Patients in group A received chemotherapy with tasisulam.

Patients in group B received chemotherapy with paclitaxel.

Toxicities:
There were 13 reported treatment-related deaths in group A due to sepsis/fever (infection).

The most severe toxicities in group B were of grade 4 and included grade 3-4 thrombocytopenia, neutropenia, and diarrhea.

Results:
The median overall survival rates for groups A and B were 6.77 and 9.36 months, respectively.

Support:
This study was supported by the pharmaceutical company Eli Lilly.

Correspondence: Dr. Jean-Jacques Grob; email: jean-jacques.grob@ap-hm.fr

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