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Ovarian Cancer treatment details. Biologic therapy. Dana-Farber Cancer Institute, Boston, MA, United States

Survival: 12.0 months
Toxicity Grade: 4
Treatments: Biologic therapy
Country: United States
City/State/Province: Boston, MA
Hospital: Dana-Farber Cancer Institute
Journal: Link
Date: 1/2013

This phase 2 study involved 64 patients with recurrent, platinum-resistant epithelial ovarian cancer (patients had been previously treated with platinum-containing therapy). The median patient age was 58 years.

Patients were treated with the biologic therapy agent called ENMD-2076, which is a small molecule kinase inhibitor that interferes with cancer cell growth.

The most severe toxicities were of grade 4 and included hypertension, brain hemorrhage, and neutropenia. Grade 3 fatigue was also reported.

The median overall survival was 12 months.

This study was supported by EntreMed, Inc., makers of the study drug.

Correspondence: Dr. Ursula A. Matulonis; email:

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