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Ovarian Cancer treatment details. Biologic therapy. Chemotherapy. M.D. Anderson Cancer Center, Houston, TX, United States

Survival: 14.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: United States
City/State/Province: Houston, TX
Hospital: M.D. Anderson Cancer Center
Journal: Link
Date: 6/2014

This phase 2 study involved previously treated, persistent or recurrent epithelial ovarian, fallopian tube or primary peritoneal carcinoma patients who were divided into two separate treatment groups. Group A consisted of 66 patients with a median age of 61.7 years. Group B had 63 patients with a median age of 61.9 years.

Patients in group A received chemotherapy with docetaxel.

Patients in group B were treated with the chemotherapy agent docetaxel and the biologic therapy agent vandetanib, a kinase inhibitor that interferes with tumor growth.

The most severe toxicities in group A were grade 4 and included leukocytosis (increased white blood cell count) and neutropenia.

There was one treatment-related death in group B due to myelosuppression (decreased blood cell count). Grade 4 neutropenia and grade 3 fatigue and rash were also reported.

The median overall survival rates for groups A and B were 18 and 14 months, respectively.

This study was partially supported by AstraZeneca, makers of vandetanib.

Correspondence: Dr. Robert L. Coleman; email:

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