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Prostate Cancer treatment details. Hormone. Massachusetts General Hospital Cancer Center, Boston, MA, United States



Survival: 11.8 months
   
Toxicity Grade: 5
   
Treatments: Hormone
   
Drugs:
Country: United States
   
City/State/Province: Boston, MA
   
Hospital: Massachusetts General Hospital Cancer Center
   
Journal: Link
   
Date: 1/2014

Description:
Patients:
This phase 3 study involved previously treated, metastatic castration-resistant prostate cancer patients who were divided into two separate treatment groups. Group A consisted of 584 patients with a median age of 69 years. Group B had 289 patients with a median age of 68 years.

Treatment:
Patients in group A were treated with the biologic therapy called sunitinib (a small-molecule receptor tyrosine kinase inhibitor) and the steroid hormone prednisone.

Patients in group B were treated with prednisone alone.

Toxicities:
Treatment-related deaths due to infection, heart/respiratory failure, and unknown causes were reported for group A. Grade 4 pulmonary embolism and anemia were also reported, as was grade 3 fatigue, hand-foot skin reaction, and mucosal inflammation/stomatitis.

Treatment-related deaths due to infection, heart/respiratory failure, and unknown causes were reported for group B. Grade 4 pulmonary embolism and anemia were also reported.

Results:
The median overall survival rates for groups A and B were 13.1 and 11.8 months, respectively.

Support:
This study was supported by Pfizer Inc.

Correspondence: Dr. M. Dror Michaelson; email: dmichaelson1@partners.org

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