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Breast Cancer treatment details. Biologic therapy. Chemotherapy. The West Clinic, Memphis, TN, United States



Survival: 32.4 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Memphis, TN
   
Hospital: The West Clinic
   
Journal: Link
   
Date: 6/2014

Description:
Patients:
This phase 2 study involved female metastatic breast cancer patients who were divided into two separate groups based on treatment and genetic status of their cancer. Group A consisted of 52 patients with HER-negative cancer with an average age of 53.6 years. Group B had 21 patients with HER-positive cancer with an average age of 52.8 years.

Treatment:
Patients in group A received biologic therapy with bevacizumab and chemotherapy with docetaxel.
Patients in group B received biologic therapy with bevacizumab and trastuzumab, and chemotherapy with docetaxel.

Toxicities:
The most severe toxicities in group A were of grade 4 and included grade 3-4 fatigue, mucosal inflammation, and high blood pressure.

The most severe toxicities in group B were of grade 4 and included grade 3-4 fatigue, nail discoloration, and urinary tract infection.

Results:
The median overall survival rates for groups A and B were 24.7 and 32.4 months, respectively.

Support:
This study was supported by the pharmaceutical company Sanofi.

Correspondence: Dr. Lee S. Schwartzberg; email: lschwartzberg@westclinic.com

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