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Rectal Cancer treatment details. Chemotherapy. Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy

Survival: ?
Toxicity Grade: 5
Treatments: Chemotherapy
Drugs: Camptosar
Country: Italy
City/State/Province: Milan
Hospital: Istituto Nazionale per lo Studio e la Cura dei Tumori
Journal: Link
Date: 1/2004

Patients: This Phase II trial involved 140 patients with metastatic colorectal cancer.

Treatment: The treatment consisted of two chemotherapy drugs – capecitabine (xeloda) and irinotecan (camptosar).

Toxicity: There were 5 deaths associated with the treatment – myocardial infection (2 patients), gastrointestinal syndrome (1 patient), and cerebrovascular accident (2 patients). Grade 3-4 toxicities included: diarrhea, nausea, vomiting, asthenia, and hand-foot syndrome.

Results: Overall survival was not discussed.

Support: This study was supported in part by a grant from Roche and one of the study’s authors is affiliated with Roche. Roche markets capecitabine.

Correspondence: Emilio Bajetta, MD

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