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Lung Cancer treatment details. Biologic therapy. Chemotherapy. LungenClinic Grosshansdorf, Grosshansdorf, Germany

Survival: 11.0 months
Toxicity Grade: 5
Treatments: Biologic therapy
Country: Germany
City/State/Province: Grosshansdorf
Hospital: LungenClinic Grosshansdorf
Journal: Link
Date: 3/2014

This phase 2 study involved previously untreated non-small cell lung cancer patients who were divided into two separate treatment groups. Group A had 34 patients with a median age of 63 years, 76.5% of whom were male. Group B had 32 patients with a median age of 62.5 years, 68.8% of whom were male.

Patients in group A received chemotherapy with vinorelbine and cisplatin, and nitroglycerin, a biologic therapy agent that inhibits production of proteins that support tumor growth.

Patients in group B received chemotherapy with vinorelbine and cisplatin only.

There was one treatment-related death in group A due to neutropenia and kidney failure. Grade 3-4 leucopenia and nausea were also reported.

There was one treatment-related death in group B due to pneumonia and sepsis. Grade 3-4 neutropenia and leucopenia were also reported.

The median overall survival rates for groups A and B were 11.0 and 12.1 months, respectively.

This study was partially supported by Pierre Fabre Pharma GmbH, which provided study drugs and employed one of the authors.

Correspondence: Dr. Martin Reck; email:

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