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Mesothelioma Cancer treatment details. Biologic therapy. Chemotherapy. Memorial Sloan Kettering Cancer Center, New York, NY, United States



Survival: 13.3 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: Pemetrexed
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan Kettering Cancer Center
   
Journal: Link
   
Date: 9/2014

Description:
Patients:
This phase 2 study involved advanced malignant pleural mesothelioma patients who had not received prior chemotherapy and who were divided into two separate treatment groups. Group A consisted of 40 patients with a median age of 64 years, 80% of whom were male. Group B had 23 patients with a median age of 66 years, 87% of whom were male.

Treatment:
Patients in group A received chemotherapy with pemetrexed and cisplatin, and with CBP501, a biologic therapy agent that interacts with a protein called calmodulin to allow more of the chemotherapy drug into the tumor cells.

Patients in group B received chemotherapy with pemetrexed and cisplatin only.

Toxicities:
There was one treatment-related death in group A due to respiratory difficulties. Grade 3-4 fatigue and vomiting, and grade 1-2 infusion-related reactions were also reported.

The most severe toxicities in group B were of grade 4 and included grade 3-4 fatigue, dehydration, and abdominal pain.

Results:
The median overall survival rates for groups A and B were 13.3 and 12.8 months, respectively.

Support:
This study was supported by CanBas.

Correspondence: Dr. L.M. Krug; email: krugl@mskcc.org

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