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Prostate Cancer treatment details. Biologic therapy. Radiation. Mayo Clinic, Rochester, MN, United States



Survival: 11.2 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Radiation
   
Drugs:
Country: United States
   
City/State/Province: Rochester, MN
   
Hospital: Mayo Clinic
   
Journal: Link
   
Date: 5/2014

Description:
Patients:
This phase 3 study involved metastatic castration-resistant prostate cancer patients with bone metastases who had received prior treatment with docetaxel. Patients were divided into two treatment groups. Group A consisted of 399 patients with a median age of 69 years. Group B had of 400 patients with a median age of 67.5 years.

Treatment:
Patients in group A were treated with radiation therapy and ipilimumab, a biologic therapy agent.

Patients in group B received radiation therapy and a placebo.

Toxicities:
Treatment-related deaths due to pneumonia and general deterioration of health were reported for group A. Grade 4 diarrhea, fatigue, and colitis were also reported.

Treatment-related deaths due to dehydration and general deterioration of health were reported for group B. Grade 4 fatigue, anemia, and back pain were also reported.

Results:
The median overall survival rates for groups A and B were 11.2 and 10.0 months, respectively.

Support:
This study was supported by Bristol-Myers Squibb.

Correspondence: Dr. Eugene D Kwon; email: kwon.eugene@mayo.edu

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