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Prostate Cancer treatment details. Radiation. Mayo Clinic, Rochester, MN, United States

Survival: 10.0 months
Toxicity Grade: 5
Treatments: Radiation
Country: United States
City/State/Province: Rochester, MN
Hospital: Mayo Clinic
Journal: Link
Date: 5/2014

This phase 3 study involved metastatic castration-resistant prostate cancer patients with bone metastases who had received prior treatment with docetaxel. Patients were divided into two treatment groups. Group A consisted of 399 patients with a median age of 69 years. Group B had of 400 patients with a median age of 67.5 years.

Patients in group A were treated with radiation therapy and ipilimumab, a biologic therapy agent.

Patients in group B received radiation therapy and a placebo.

Treatment-related deaths due to pneumonia and general deterioration of health were reported for group A. Grade 4 diarrhea, fatigue, and colitis were also reported.

Treatment-related deaths due to dehydration and general deterioration of health were reported for group B. Grade 4 fatigue, anemia, and back pain were also reported.

The median overall survival rates for groups A and B were 11.2 and 10.0 months, respectively.

This study was supported by Bristol-Myers Squibb.

Correspondence: Dr. Eugene D Kwon; email:

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