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Brain Cancer treatment details. Gene Therapy. The University of Texas M.D. Anderson Cancer Center, Houston, Texas, United States



Survival: 9.9 months
   
Toxicity Grade: 4
   
Treatments: Gene Therapy
   
Drugs:
Country: United States
   
City/State/Province: Houston, Texas
   
Hospital: The University of Texas M.D. Anderson Cancer Center
   
Journal: Link
   
Date: 7/2003

Description:
Patients: This Phase I study involved 15 patients with recurrent gliomas. Of the fifteen, 13 patients had recurrent glioblastoma multiforme. All patients had prior radiotherapy and most had prior chemotherapy.

Treatment: The treatment consisted of p53 gene therapy using an adenovirus vector (Ad-p53, INGN 201).

Toxicity: Toxicities included seizure (grade 2,4), CNS hemorrhage (grade 3), headache (grade 1-3), speech impairment (grade 1-3), fatigue (grade 1-2), and vomiting (grade 1-2).

Results: Median overall survival was 43 weeks, 9.9 months.

Correspondence: Frederick F. Lang, MD

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