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Mesothelioma Cancer treatment details. Biologic therapy. Chemotherapy. National Cancer Institute, Bethesda, MD, United States



Survival: 14.8 months
   
Toxicity Grade: 4
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs: Pemetrexed
Country: United States
   
City/State/Province: Bethesda, MD
   
Hospital: National Cancer Institute
   
Journal: Link
   
Date: 12/2014

Description:
Patients:
This phase 2 study involved 89 malignant pleural mesothelioma patients. The median patient age was 67 years and 78% were male.

Treatment:
Patients received chemotherapy with pemetrexed and cisplatin, and they received biologic therapy with amatuximab, a monoclonal antibody to mesothelin, a protein on the surface of cancer cells.

Toxicities:
The most severe toxicities were of grade 4 and included grade 3-4 neutropenia, fatigue, anorexia, and nausea.

Results:
The median overall survival was 14.8 months.

Support:
This study was partially supported by Morphotek, Inc. (maker of study drug).

Correspondence: Dr. Raffit Hassan; email: hassanr@mail.nih.gov

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