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Mesothelioma Cancer treatment details. Biologic therapy. Chemotherapy. National Cancer Institute, Bethesda, MD, United States

Survival: 14.8 months
Toxicity Grade: 4
Treatments: Biologic therapy
Drugs: Pemetrexed
Country: United States
City/State/Province: Bethesda, MD
Hospital: National Cancer Institute
Journal: Link
Date: 12/2014

This phase 2 study involved 89 malignant pleural mesothelioma patients. The median patient age was 67 years and 78% were male.

Patients received chemotherapy with pemetrexed and cisplatin, and they received biologic therapy with amatuximab, a monoclonal antibody to mesothelin, a protein on the surface of cancer cells.

The most severe toxicities were of grade 4 and included grade 3-4 neutropenia, fatigue, anorexia, and nausea.

The median overall survival was 14.8 months.

This study was partially supported by Morphotek, Inc. (maker of study drug).

Correspondence: Dr. Raffit Hassan; email:

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