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Ovarian Cancer treatment details. Immunotherapy. University of Alabama School of Medicine, Birmingham, AL, United States



Survival: 9.1 months
   
Toxicity Grade: 3
   
Treatments: Immunotherapy
   
Drugs:
Country: United States
   
City/State/Province: Birmingham, AL
   
Hospital: University of Alabama School of Medicine
   
Journal: Link
   
Date: 6/2014

Description:
Patients:
This phase 2 study involved 20 recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer patients who had received prior platinum-based chemotherapy. The median patient age was 57 years.

Treatment:
Patients received immunotherapy with EGEN-001, a form of interleukin-12 (IL-12) that stimulates the immune system to attack cancer cells.

Toxicities:
The most severe toxicities were of grade 3 and included nausea and vomiting (2 patients), anemia (1 patient), and decreased lymphocyte count (1 patient). Grade 1-2 fever, chills, abdominal pain, and anemia were also reported.

Results:
The median overall survival was 9.17 months.

Correspondence: Dr. Ronald D. Alvarez; email: rdalvarez@uab.edu

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