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Rectal Cancer treatment details. Chemotherapy. Charite-Universitaetsmedizin Berlin, Hindenburgdamm, Germany

Survival: ?
Toxicity Grade: 4
Treatments: Chemotherapy
Drugs: Eloxatin
Country: Germany
City/State/Province: Hindenburgdamm
Hospital: Charite-Universitaetsmedizin Berlin
Journal: Link
Date: 8/2004

Patients: This Phase I/II study involved 21 patients with metastatic colorectal cancer that had progressed (increase in tumor size or tumor spread) during or after 5-FU chemotherapy.

Treatment: The treatment consisted of two chemotherapy drugs oxaliplatin (eloxatin) and topotecan (hycamtin).

Toxicity: Grade 4 toxicities included: thrombocytopenia and neutropenia. Other toxicities included paraesthesia (grade 1), diarrhea (grade 2-3), and mucositis (grade 3).

Results: The median progression-free survival was 5 months. Overall survival was not discussed.

Correspondence: G. Hutter, MD

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