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Prostate Cancer treatment details. Biologic therapy. Chemotherapy. University of Michigan, Ann Arbor, Michigan, United States



Survival: 9.1 months
   
Toxicity Grade: 5
   
Treatments: Biologic therapy
Chemotherapy
   
Drugs:
Country: United States
   
City/State/Province: Ann Arbor, Michigan
   
Hospital: University of Michigan
   
Journal: Link
   
Date: 10/2014

Description:
Patients:
This study involved 26 metastatic castration-resistant prostate cancer patients who had been previously treated with docetaxel. The median patient age was 67.0 years.

Treatment:
Patients received chemotherapy with temozolomide and biologic therapy with veliparib, an inhibitor of the PARP protein that interferes with cancer cell growth.

Toxicities:
There was one reported treatment-related death due to hepatorenal syndrome (liver and kidney toxicity). Grade 3-4 colitis, fatigue, neutropenia, and anemia were also reported.

Results:
The median overall survival was 9.1 months.

Support:
This study was supported by AbbVie Inc.

Correspondence: Dr. ; email: mahahuss@med.umich.edu

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